Characterizing Cefepime Neurotoxicity: A Systemic Review

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Characterizing Cefepime Neurotoxicity: A Systematic Review

Neurotoxicity due to cefepime has not been well characterized. We performed a systematic review of the literature and included 5 additional cases from our center. Of the 198 cases found, the mean age was 67 years and 87% of patients had renal dysfunction. The most common clinical features were diminished level of consciousness (80%), disorientation/agitation (47%), and myoclonus (40%). It is wo...

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Cefepime Neurotoxicity in Patients with Renal Insufficiency

Cefepime is a fourth-generation cephalosporin that is active against both gram-positive and gram-negative organisms. It is administered parenterally for the treatment of severe infections. Approximately 85% of the drug is excreted unchanged by the kidneys. Neurotoxicity in patients with renal failure who are treated with cefepime has been reported sporadically. We report on two senile patients ...

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Cefepime induced neurotoxicity: A case series and review of the literature

Cefepime is a fourth generation cephalosporin which is bactericidal for broad spectrum of organisms. This is a case-series of three patients who presented to our hospital with confusion secondary to cefepime use to treat urinary tract infection (UTI) and health care associated pneumonia (HCAP), after excluding other common etiologies of altered mental status (AMS). Of these three patients, one ...

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ژورنال

عنوان ژورنال: Open Forum Infectious Diseases

سال: 2016

ISSN: 2328-8957

DOI: 10.1093/ofid/ofw172.1348